At UTgene, we specialize in providing tailored solutions to our clients in the laboratory, enabling them to unlock the full potential of mRNA in research, therapeutics, and biotechnology.

Our specialized service focuses on optimizing LNP formulations to facilitate the efficient delivery of these RNA molecules. The process of LNP formulation development involves several key steps. Our experienced team begins by carefully selecting appropriate lipids and other components that are essential for ensuring the stability and efficacy of the LNPs. These lipids can be modified or combined in specific ratios to tailor the properties of the LNPs to suit the unique requirements of each RNA modality. Once the formulation is prepared, it undergoes rigorous testing and optimization. We evaluate critical factors such as particle size, surface charge, stability, and encapsulation efficiency to ensure the optimal performance of the LNPs. Our goal is to achieve the ideal balance of these parameters to enhance the delivery efficiency and maximize the therapeutic potential of the RNA-based modalities.

The development of LNP formulations at Utgene is accompanied by stringent quality control measures to ensure the highest standards of uniformity, stability, and efficacy. We employ a range of advanced techniques and studies to thoroughly assess the physical properties and performance of our optimized LNPs. Dynamic light scattering, zeta potential analysis, and transmission electron microscopy are instrumental in evaluating the physical characteristics of the LNPs. These techniques enable us to measure particle size, surface charge, and morphology, providing valuable insights into the uniformity and stability of the formulations. Additionally, in vitro and in vivo studies are conducted to evaluate the delivery efficiency and therapeutic potential of the optimized LNP formulations, upon clients requests.

Moreover, through our close collaboration with our trusted partner, we are able to offer additional capabilities in the field of extrahepatic delivery and an enhanced muscle injection formulation for vaccines. With our specialized formulations, we can efficiently deliver cargo to specific target organs such as the liver, spleen, and lung. This opens up new possibilities for targeting diseases and achieving desired therapeutic outcomes. It is worth noting that the lipids and formulations we utilize in our services are backed by comprehensive intellectual property (IP).

Contact us today to learn more about our services and how we can collaborate to bring your vision to life. Together, we can make a lasting impact in the field of drug delivery and therapeutics.