Partner with Utgene to advance antibody discovery efforts and drive the development of novel therapeutics.

Therapeutic antibodies targeting of multiple transmembrane proteins, such as the challenging seven transmembrane G-protein coupled receptors (GPCRs), has long posed difficulties for antibody discovery and development. One of the major obstacles is obtaining purified, stable antigens in the correct conformation. Based on the recent learnings from mRNA vaccines, mRNA technology offers a promising solution for antibody discovery against these challenging targets.

At Utgene, we have successfully supported clients in the immunization of animals, including rodents and rabbits, to generate GPCR antibodies. Our approach involves encoding the full-length sequences of GPCRs in our proprietary backbone, ensuring optimal expression and high-level production. Additionally, we carefully select LNP formulations with high immunogenicity to maximize the effectiveness of the immunization process.

Partner with Utgene and leverage our expertise in mRNA-based immunization to unlock the potential of targeting hard-to-target transmembrane proteins. Together, we can advance antibody discovery efforts and drive the development of novel therapeutics. Contact us today to learn more about our services and explore the exciting possibilities of our innovative approach.